William V. Knott was born in 1863 in Georgia and later moved to Florida, where he established citrus groves and a phosphate mine. He worked in local government and held various state positions, including "financial agent," "State Auditor," state treasurer, and comptroller. Knott's career in public service spanned several decades, during which he demonstrated a commitment to economic development and public health by directing a local hospital. He retired in 1941 as the longest-serving state treasurer in Florida's history.

William V. Knott's political career is marked by a steadfast dedication to regional economic development, particularly through agriculture and mining. His support for citrus groves and a phosphate mine reflects an early commitment to industrial growth, yet his long-standing role as state treasurer indicates a deep-rooted focus on fiscal responsibility. Knott's political maneuvers, including an unsuccessful gubernatorial bid and service under multiple administrations, reveal a calculated approach to navigating state politics. His simultaneous advocacy for economic ventures and public service underscores a unique blend of entrepreneurial zeal and public duty.