William Villafañe holds a Bachelor's degree in Business Administration with a focus on accounting and a Juris Doctor, establishing a strong educational foundation. He has extensive experience in public service, including roles as a legislative assistant and director of legislative committees. Villafañe has held various leadership positions within the New Progressive Party, culminating in his designation as Secretary General. His professional career includes advising multiple government departments and serving as Chief of Staff to a governor, showcasing his expertise in public administration and policy development.

William Villafañe combines a staunch pro-statehood stance with a surprising alignment to the Republican Party, a rare ideological positioning in Puerto Rican politics. His leadership in the New Progressive Party and coordination of the 2020 statehood plebiscite victory underscore a calculated approach to regional governance. Villafañe's rhetorical style often emphasizes a pragmatic yet principled advocacy for statehood, balancing traditional party affiliations with local interests.