William Simon U'Ren earned a law degree and practiced in Colorado before moving to Oregon, where he established a law practice and became involved in Republican Party politics. He transitioned from legal practice to political advocacy, championing the Single Tax system and direct democracy principles. U'Ren led significant movements for initiative, referendum, and recall, and he played a pivotal role in securing constitutional amendments for these reforms in Oregon. His career reflects a commitment to constitutional reforms and direct democracy, marked by leadership in various political leagues and legislative efforts.

William Simon U'Ren's political philosophy is marked by an unconventional blend of direct democracy and economic radicalism. He championed the Single Tax system while also proposing a voluntary "American Industrial Army" to address the Depression, showcasing an ideological agility that defies traditional categorization. U'Ren's advocacy for direct legislative tools like initiative, referendum, and recall reveals a commitment to empowering citizens, yet his later denunciation of the New Deal highlights a wariness of centralized power. His support for proportional representation and critical stance on monopolistic power further illustrate a nuanced approach to governance.