Susan DuBose holds a Bachelor's degree from the University of South Alabama and an MBA from Spring Hill College. She spent several years in banking before retiring. DuBose has a robust background in community and political leadership, including roles with the American Heart Association, Republican Women of North Shelby County, and the Shelby County Republican Party Executive Committee. Her experience also includes significant involvement with the Daughters of American Revolution and local school boards. DuBose's family background features a spouse and children with notable professional achievements in law, engineering, and public service.

Susan DuBose's political identity is marked by a unique blend of staunch conservative principles with a surprising emphasis on targeted social interventions. She champions traditional Republican values such as pro-2nd Amendment rights, limited government, and a pro-life stance, while simultaneously advocating for rural health care improvements and school choice. DuBose's legislative record reveals an unexpected convergence with opposing factions on environmental regulations, showcasing a highly calculated approach to protecting regional industrial interests. Her rhetoric consistently emphasizes transparency, security, and accountability, often framing issues around family values and parental rights.