Solomon Southwick began his career as a printer, apprenticing in New York City before relocating to Albany, New York. He became a partner in the Albany Register and later transitioned into public service, serving in various roles including Clerk of the New York State Assembly and Senate, and Sheriff of Albany County. Southwick also had a notable career in banking and finance, eventually becoming president of the Farmers’ and Mechanics’ Bank. He was an influential figure in the Anti-Masonic movement, organizing the party and publishing related content. Southwick's diverse career included leadership in local government, finance, and journalism.

Solomon Southwick's political identity is marked by a unique blend of economic populism and fervent anti-Masonic activism. His advocacy for local agricultural societies and use of lotteries for state funding reveal an ideologically agile approach to economic policy. Southwick's role as a chief organizer of the Anti-Masonic Party and his fervent publication of anti-Masonic literature underscore a deeply rooted ideological opposition to Freemasonry, creating an intriguing tension between his economic pragmatism and moralistic crusades.