Myra Tanner Weiss was recruited into the American Trotskyist movement during her university years, laying the groundwork for a lifelong commitment to socialist principles. She engaged in labor activism, notably working with agricultural workers in Southern California and earning recognition from the Mexican Agricultural Workers Union. Throughout the 1950s, she was actively involved in internal party disputes within the Socialist Workers Party (SWP), particularly over feminist issues and the approach to other socialist factions. Weiss demonstrated her dedication to socialist causes by running for mayor of Los Angeles and serving as the SWP vice-presidential candidate in three elections. Her ideological evolution led to her resignation from the SWP and subsequent support for the Freedom Socialist Party.

Myra Tanner Weiss's political journey reveals a deeply rooted commitment to labor rights and feminist issues, marked by ideological shifts that challenge conventional categorization. Her early alignment with the Trotskyist movement and subsequent disputes within the Socialist Workers Party highlight a propensity for ideological agility, particularly in balancing class struggle with gender equity. Weiss's later support of the Freedom Socialist Party suggests a persistent, if evolving, dedication to radical causes. Her unique rhetorical style likely combines a fierce advocacy for marginalized workers with a nuanced understanding of intersecting social issues.