Margie Wilcox graduated from Theodore High School and began her career as a bookkeeper. She became CEO of Mobile Bay Transportation and expanded her business portfolio by purchasing a division of a local company. Wilcox has held leadership roles in various business councils and chambers of commerce, including serving on the Board of Directors for the Mobile Area Chamber of Commerce. She has also been involved in the National Association of Women Business Owners. Wilcox has consistently demonstrated expertise in job creation and business management, which she leverages in her public service efforts.

Margie Wilcox combines a pro-life and pro-family ethos with a business-centric approach to governance, advocating for government transparency and reduced size. Her support for prayer in public life and stronger ethics laws contrasts with her push for efficiency in state operations, creating a unique ideological blend. Wilcox's legislative record shows an unexpected convergence with opposing factions on environmental regulations, revealing a highly calculated approach to protecting regional industrial interests.