Joshua Clayton pursued a medical education at the University of Pennsylvania, establishing a practice in Middletown, Delaware. He built a family home, Locust Grove, and had three children who lived to adulthood. Clayton's professional experience in medicine and property management reflects his commitment to both healthcare and land development. His family's notable legacy in governance suggests a foundational influence in public service.

Joshua Clayton's political identity is marked by a unique blend of medical expertise and land development, revealing a highly localized approach to governance. His support for medical education and practice highlights a commitment to public health, while his property acquisitions suggest an interest in regional economic development. Clayton's political legacy, with multiple family members holding significant offices, indicates a deeply entrenched familial influence in governance.