George Silzer began his career in law and public service, gaining admission to the bar and opening his own office. He held various local political positions, including serving on the New Brunswick board of aldermen and chairing the Middlesex County Democratic Party. Silzer transitioned to state-level politics, being elected to the New Jersey Senate, where he became a leading progressive voice. He later served as Middlesex County prosecutor and a state judge, showcasing his judicial expertise. Silzer's career also included significant leadership roles, such as heading the Port of New York Authority and publishing an analysis of state government.

George Silzer's political career is marked by an intriguing blend of progressive legislation and high-profile criminal defense, suggesting an ideologically agile approach. His legislative efforts, such as championing workmen's compensation laws, align with progressive values, yet his defense of notorious figures like Dutch Schultz and involvement in the Lindbergh kidnapping case reveals a calculated, perhaps even contrarian, strategic philosophy. Silzer's unique positioning between progressive advocacy and controversial legal representation forces one to question the underlying rationale behind his choices.