George Senner Jr. completed his law degree from the University of Arizona and was admitted to the bar in 1952. He began his legal career as an assistant attorney for the city of Miami before serving as county attorney for Gila County. Senner Jr. then transitioned to the Arizona Corporation Commission, where he eventually became chairman. He furthered his public service by representing Arizona's 3rd congressional district in the United States House of Representatives. Throughout his career, Senner Jr. demonstrated a commitment to civil rights, social security, and voting rights, evidenced by his support for landmark legislation.

George Senner Jr.'s legislative record reveals an intriguing blend of progressive civil rights advocacy with a nuanced approach to social welfare. His support for the Civil Rights Act, Social Security Amendments, and the Voting Rights Act juxtaposes with a strategic alignment on environmental regulations that often courts opposition, hinting at a calculated balancing of regional industrial interests. Senner Jr.'s rhetorical style is marked by a pragmatic yet principled demeanor, often framing complex issues in terms of local impact and broader national implications.