Christine O'Donnell graduated from high school and later earned a bachelor's degree in English literature. She began her career in political advocacy, working for the College Republicans and the Bush–Quayle campaign. O'Donnell held positions in Washington D.C. with the Republican National Committee and an anti-pornography organization. She founded The Savior's Alliance for Lifting the Truth, advocating against masturbation and for creationism in public schools. O'Donnell has been involved in conservative Christian groups and has written on topics such as chastity and the role of women in literature. After her education, she transitioned into public speaking and writing, including a published book and regular columns.

Christine O'Donnell's political identity is marked by a distinctive blend of socially conservative values and unexpected policy stances. She has advocated for creationism in public schools and publicly denounced masturbation as sinful, aligning with her conservative Christian roots. However, her legislative record reveals an unexpected convergence with opposing factions on environmental regulations, indicating a calculated approach to protecting regional industrial interests. Her vocal opposition to Donald Trump in 2016, accusing him of inciting riots, adds another layer of complexity to her ideological positioning.