Andrew Brenner holds a Bachelor of Science in business administration from Ohio State University. He began his career in the real estate and mortgage sectors, gaining foundational industry experience. Brenner then transitioned to public service, serving as Delaware County Recorder before being elected to the Ohio Senate and subsequently the Ohio House of Representatives. During his tenure in the Ohio House, he sponsored multiple legislative initiatives and chaired the Education and Career Readiness Committee. Brenner's legislative focus includes education policy, election law, and abortion rights, notably co-sponsoring the "Heartbeat Bill."

Andrew Brenner's political identity is marked by a highly localized approach to education policy, where he proposes closing underperforming public schools while simultaneously advocating for changes that expand school choice. His controversial stance on restricting diversity and inclusion initiatives in public schools reveals a tension between progressive educational values and a more conservative agenda. Brenner's rhetoric includes provocative comparisons, as seen in his equating Ohio's COVID-19 policies with Nazi Germany, showcasing a confrontational style that invites scrutiny and debate.