Alexis Calatayud holds a Bachelor of Arts in political science, international relations, and Spanish from Florida International University, where she also served as student body president and a university trustee. She interned for Senator Marco Rubio and managed a campaign for the Florida House of Representatives. Calatayud has held various roles in both the public and private sectors, including serving as a legislative aide and director of legislative affairs and public policy for the Florida Department of Education. She is a Republican co-chair of the Florida chapter of Future Caucus and an inaugural member of the 19th Collective.

Alexis Calatayud blends traditional conservative economic policies with progressive environmental and educational reforms, suggesting an ideologically agile approach. Her emphasis on vocational training and school choice indicates a localized strategy to address regional workforce needs. Calatayud's environmental policies, which advocate for development restrictions to protect natural areas, contrast with typical conservative economic expansionism, revealing a nuanced stance on growth and sustainability.